Spinal Fusion

  Stem cell therapy for Spinal Fusion

Spinal fusion is surgery to join together two bones (vertebrae) in the spine. Fusion permanently joins two bones together so there is no longer movement between them. Fusing of the spine is used primarily to eliminate the pain caused by abnormal motion of the vertebrae by immobilizing the faulty vertebrae themselves. Spinal fusion is done most commonly in the lumbar region of the spine, but it is also used to treat cervical and thoracic problems. The indications for lumbar spinal fusion are controversial. People rarely have problems with the thoracic spine because there is little normal motion in the thoracic spine.

Spinal fusion may relieve symptoms of many back conditions, including:

  • Degenerative disk disease
  • Spondylolisthesis
  • Spinal stenosis
  • Scoliosis
  • Fracture
  • Infection
  • Tumor

There are different methods of spinal fusion.

1. Bone is taken from the pelvic bone or other source. The bone is used to make a bridge between vertebrae that are next to each other. This bone graft helps new bone grow.
2. Metal implants (cages, pedicle screws often made from titanium) during TLIF, PLIF, ALIF are used to hold the vertebrae together until new bone grows between them.

Treatment of Spinal Fusion using of Bone Marrow Derived Stem Cells:-

The primary bone-forming cell in the body is the osteoblast and its precursor is the MSC. Bone formation occurs as the extracellular matrix, which is produced by the osteoblast, becomes mineralized. Osteoprogenitors refer to all the cell stages stemming from Mesenchymal stem cells up to the osteoblast. This naturally occurring differentiation process is regulated by a series of naturally occurring proteins, or growth factors, that eventually guide the MSC to form osteoblasts.

Follow-up with patients:-

Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 month intervals to monitor all the evaluation.

Scientific Papers:-

1. Johanson et al. 2008 , Neurosurgical associates, Texas, USA. Concentrated Autologous Adult Stem Cells vs. Autologous Iliac Crest Bone for Instrumented Fusion of the Lumbar Spine: Clinical and Laboratory Results for Two Consecutive Patients

2. Shen et al. 2005, The Spine Journal. Cell Technology for Spinal Fusion. s 3.Robert et al. 2005, The Journal of Bone and Joint Surgery, Aspiration of Osteoprogenitor cells for augmenting Spinal Fusion: Comparison of Progenitor cell concentrations from the Vertebral Body and Iliac

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