Retinitis Pigmentosa

  Stem cell therapy for Retinitis Pigmentosa

Retinitis pigmentosa (RP) is a heritable group of blinding diseases characterized by progressive peripheral vision loss and night vision difficulties. RP constitutes abnormalities in photoreceptor cells (rods and cones) and retinal pigment epithelium (RPE) dystrophies caused by molecular defects in more than 40 different genes.

RP can be passed on by all types of inheritance: approximately 20% of RP is autosomal dominant (ADRP), 20% is autosomal recessive (ARRP), and 10% is X linked (XLRP), while the remaining 50% is found in patients without any known affected relatives.

Stem Cell Therapy for Retinitis Pigmentosa (RP):-

Currently no definitive treatment for retinitis pigmentosa exists because it is a progressive disease that damage photoreceptors cells (rods and cones) or the retinal pigment epithelium (RPE) of the retina. Scientifically proved that stem cell transplantation via “retrobulbar and intravitreous” may prevent further loss of photoreceptor cells and retinal pigment epithelial cells (RPE) and can regenerate photoreceptor cells and RPE cells (Smith et al. 2004).

Stem cell transplantation for “retinitis pigmentosa” treatment provides some major advantages are as follow:-
1. Regenerate Retinal Pigment Epithelial cells
2. Regenerate of photoreceptor cells
3. Provides revascularization
4. Activate resident stem cells

Follow-up with patients:-

Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 month intervals to monitor all the evaluation.

Scientific Papers:-

1. Smith et al. 2004 (The Journal of Clinical Investigation). Bone marrow–derived stem cells preserve cone vision in retinitis pigmentosa.

2. Dahlmann-Noor et al.2010 (Can J Opthalmol). Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve.

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